Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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ea0089c28 | Clinical – Nuclear Medicine/Interventional Radiology/Imaging | NANETS2022

Diagnostic Performance of PET or PET/CT Utilizing 18F-DOPA, 68Ga-DOTATATE, 18F-FDG, 18F-FDA, and CT and MRI in the Detection of MEN2A-related-pheochromocytoma

Jha Abhishek , Patel Mayank , Ling Alexander , Chen Clara C. , Millo Corina , Charles Kailah , Talvacchio Sara , Ezemobi Josephine , Herscovitch Peter , Lin Frank I. , Nilubol Naris , Taieb David , Cahid Civelek Ali , Carrasquillo Jorge , Pacak Karel

Background: Pheochromocytoma (PHEO) is a rare neuroendocrine tumor arising from chromaffin cells of adrenal gland that can cause life-threatening complications due to overproduction of catecholamines. Per EANM/SNMMI 2019 guidelines for radionuclide imaging of PHEO and paraganglioma, 18F-fluoro-L-dihydroxyphenylalanine (18F-FDOPA) is recommended as a positron emission tomography (PET) radiotracer of choice followed by 68Ga-DOTA(0)-Tyr(3)-octreot...
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ea0089c29 | Clinical – Nuclear Medicine/Interventional Radiology/Imaging | NANETS2022

Diagnostic Performance of PET or PET/CT Utilizing 18F-DOPA, 68Ga-DOTATATE, 18F-FDG, 18F-FDA, and CT and MRI the Detection of VHL-related Pheochromocytoma

Jha Abhishek , Patel Mayank , Ling Alexander , Chen Clara C. , Millo Corina , Charles Kailah , Talvacchio Sara , Ezemobi Josephine , Herscovitch Peter , Lin Frank I. , Nilubol Naris , Taieb David , Cahid Civelek Ali , Carrasquillo Jorge , Pacak Karel

Background: The purpose of this prospective study was to evaluate and compare the detection rates of 18F-L-dihydroxyphenylalanine (18F-FDOPA), 68Ga-DOTATATE, 18F-FDG, and 18F-fluorodopamine (18F-FDA) PET or positron emission tomography/computed tomography (PET/CT), computed tomography (CT), and magnetic resonance imaging (MRI) in the detection of VHL-related pheochromocytoma (PHEO).<p class="abstext...
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ea0098c21 | Clinical – Nuclear Medicine/Interventional Radiology/Imaging | NANETS2023

Ratio of total uptake volume on DOTATATE vs FDG PET as a predictive marker of treatment efficacy of Lu-177-DOTATATE in metastatic pheochromocytoma

Lin Frank I. , Del Rivero Jaydira , Carrasquillo Jorge , Shamis Inna , Zou Joy , Turkbey Baris , Jha Abhishek , Klubo Joanna , Adler Steve , Mena Esther , Lindenberg Liza , Chen Clara , Herscovitch Peter , Millo Corina , Pacak Karel

Background: Pheochromocytoma/Paraganglioma (PPGL) are rare neuroendocrine tumors that expresses somatostatin receptors (SSTR) and can be treated with radiolabeled somatostatin analogues such as Lu-177-DOTATATE. Ga-68-DOTATATE PET scans show the distribution and density of SSTR+ tumors, and F-18-FDG PET scans show hypermetabolism in lesions. Total uptake volumes (TUV) for each respective scan can be obtained consistently and semi-automatically using standardized workflow in ima...
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ea0098c22 | Clinical – Nuclear Medicine/Interventional Radiology/Imaging | NANETS2023

Phase 2 trial of lu-177-DOTATATE in metastatic or inoperable pheochromocytoma/paraganglioma: interim analysis results

Lin Frank I. , Del Rivero Jaydira , Carrasquillo Jorge , Shamis Inna , Zou Joy , Turkbey Baris , Jha Abhishek , Klubo Joanna , Teng Ya-ting , Mena Esther , Lindenberg Liza , Chen Clara , Herscovitch Peter , Millo Corina , Pacak Karel

Background: Pheochromocytoma/Paraganglioma (PPGL) are rare neuroendocrine tumors that expresses somatostatin receptors (SSTR) and can be treated with radiolabeled somatostatin analogues such as Lu-177-DOTATATE. This study is the first prospective study to examine the safety and efficacy of Lu-177-DOTATATE in the treatment of metastatic or inoperable PPGL in a phase 2 clinical trial setting, and results from a planned interim analysis are presented.Method...
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ea0089c27 | Clinical – Nuclear Medicine/Interventional Radiology/Imaging | NANETS2022

Performance of 68Ga-DOTATATE PET/CT, 18F-FDG PET/CT, CT, and MRI Spine in the Detection of Spinal Bone Metastases in Metastatic Pheochromocytoma/Paraganglioma

Jha Abhishek , Patel Mayank , Saboury Babak , Millo Corina , Ling Alexander , Shah Ritu , Chen Clara C. , Meuter Leah , Talvacchio Sara , Knue Marianne , Lin Frank I. , O'Sullivan Coyne Geraldine , Chen Alice P. , Nilubol Naris , Herscovitch Peter , Taieb David , Cahid Civelek Ali , Carrasquillo Jorge A. , Pacak Karel

Background: To evaluate and compare the diagnostic performance of 68Ga-DOTATATE PET/CT to 18F-FDG PET/CT, CT of neck, chest, abdomen and pelvis (CT), and MRI of cervical, thoracic, and lumbar spine (MRI spine), for the detection of spinal bone metastases in metastatic pheochromocytoma and/or paraganglioma (PPGL).Methods: Between 2014 and 2019, 41 consecutive metastatic PPGL patients (19 females; mean age, 43 years) underwent 68...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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